Proteins/UNIPROT:P49638

TTPA

ProteinUNIPROT:P49638

Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity)..

Function from UniProtKB (P49638), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

familial isolated deficiency of vitamin E has a germline basis in TTPADiseaseGenCC HGNC:12404|MONDO:0010188Inferred only

Statements

6 statements

6 statements · 3 reference databases · Subject: TTPA · Sources: gene ontology, Hetionet, Reactome

Order

APP interacts with TTPAProteinHetionet hetionet:interacts:351-7274Inferred only
TTPA participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
TTPA participates in Metabolism of fat-soluble vitaminsPathwayReactome R-HSA-6806667Inferred only
TTPA participates in Metabolism of vitamins and cofactorsPathwayReactome R-HSA-196854Inferred only
TTPA participates in Vitamin E transportPathwayReactome R-HSA-8877627Inferred only
TTPA regulates negative regulation of establishment of blood-brain barrierBiological processgene ontology P49638|GO:0090212Inferred only

Other names

3 names

Resolves to: TTPA

Also called: Alpha-tocopherol transfer proteinAlpha-TTPTPP1

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