Proteins/UNIPROT:Q6NXR4

TTI2

ProteinUNIPROT:Q6NXR4

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs..

Function from UniProtKB (Q6NXR4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

severe intellectual disability-short stature-behavioral abnormalities-facial dysmorphism syndrome has a germline basis in TTI2DiseaseGenCC HGNC:26262|MONDO:0014238Inferred only

Statements

8 statements

8 statements · 2 reference databases · Subject: TTI2 · Sources: gene ontology, Hetionet

Order

ZSCAN12 covaries with TTI2ProteinHetionet hetionet:covaries:80185-9753Inferred only
UBC interacts with TTI2ProteinHetionet hetionet:interacts:7316-80185Inferred only
TTI2 regulates positive regulation of DNA damage checkpointBiological processgene ontology Q6NXR4|GO:2000003Inferred only
NME1 decreases the expression of TTI2ProteinHetionet hetionet:regulates:4830-80185Inferred only
NMT1 increases the expression of TTI2ProteinHetionet hetionet:regulates:4836-80185Inferred only
NR1H2 decreases the expression of TTI2ProteinHetionet hetionet:regulates:7376-80185Inferred only
RPA1 increases the expression of TTI2ProteinHetionet hetionet:regulates:6117-80185Inferred only
TRIM62 increases the expression of TTI2ProteinHetionet hetionet:regulates:55223-80185Inferred only

Other names

2 names

Resolves to: TTI2

Also called: C8orf41TELO2-interacting protein 2

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