TRIM9

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. Regulates filopodial dynamics in brain by promoting the ubiqutination and degradation of actin polymerase VASP; this activity is antagonized by TRIM67 (By similarity). May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation..

Function from UniProtKB (Q9C026), read 2026-09-23. CC BY 4.0.