Proteins/UNIPROT:Q8IWZ4

TRIM48

ProteinUNIPROT:Q8IWZ4

E3 ubiquitin-protein ligase which promotes K48-linked polyubiquitination of protein methyltransferase PRMT1, leading to PRMT1 degradation. This suppresses methylation of the PRMT1 substrate MAP3K5/ASK1, promoting its activation and increasing MAP3K5-dependent cell death induced by oxidative stress. TRIM48-mediated ubiquitination of PRMT1 also suppresses methylation of FOXO1 by PRMT1, leading to inhibition of FOXO1 transcriptional activity. Additionally, it inhibits RIG-I-mediated antiviral signaling, functioning as an inducible negative feedback regulator of this pathway..

Function from UniProtKB (Q8IWZ4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

6 statements

6 statements · 3 reference databases · Subject: TRIM48 · Sources: gene ontology, Hetionet, Reactome

Order

UBC interacts with TRIM48ProteinHetionet hetionet:interacts:7316-79097Inferred only
TRIM48 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
TRIM48 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
TRIM48 participates in Interferon gamma signalingPathwayReactome R-HSA-877300Inferred only
TRIM48 participates in Interferon SignalingPathwayReactome R-HSA-913531Inferred only
TRIM48 regulates regulation of gene expressionBiological processgene ontology Q8IWZ4|GO:0010468Inferred only

Other names

3 names

Resolves to: TRIM48

Also called: RING finger protein 101RNF101Tripartite motif-containing protein 48

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