Proteins/UNIPROT:Q6P9F5

TRIM40

ProteinUNIPROT:Q6P9F5

E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response. Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation. Also promotes the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation..

Function from UniProtKB (Q6P9F5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 2 reference databases · Subject: TRIM40 · Sources: gene ontology, Hetionet

Order

APP interacts with TRIM40ProteinHetionet hetionet:interacts:135644-351Inferred only
CHUK interacts with TRIM40ProteinHetionet hetionet:interacts:1147-135644Inferred only
IKBKB interacts with TRIM40ProteinHetionet hetionet:interacts:135644-3551Inferred only
IKBKG interacts with TRIM40ProteinHetionet hetionet:interacts:135644-8517Inferred only
TRIM40 regulates negative regulation of canonical NF-kappaB signal transductionBiological processgene ontology Q6P9F5|GO:0043124Inferred only
TRIM40 regulates negative regulation of non-canonical NF-kappaB signal transductionBiological processgene ontology Q6P9F5|GO:1901223Inferred only
TRIM40 regulates negative regulation of protein catabolic processBiological processgene ontology Q6P9F5|GO:0042177Inferred only
TRIM40 regulates negative regulation of protein localization to nucleusBiological processgene ontology Q6P9F5|GO:1900181Inferred only

Other names

3 names

Resolves to: TRIM40

Also called: Probable E3 NEDD8-protein ligaseRING finger protein 35RNF35

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