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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:P34981

TRHR

Protein·UNIPROT:P34981

Open in the graph

Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway..

Function from UniProtKB (P34981), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

hypothyroidism, congenital, nongoitrous, 7 has a germline basis in TRHRDiseaseGenCC HGNC:12299|MONDO:0032819Inferred only

Statements

12 statements

12 statements · 3 reference databases · Subject: TRHR · Sources: Hetionet, Reactome, WikiPathways

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TRHR covaries with OR2F1ProteinHetionet hetionet:covaries:26211-7201Inferred only
ARRB1 interacts with TRHRProteinHetionet hetionet:interacts:408-7201Inferred only
TRH interacts with TRHRProteinHetionet hetionet:interacts:7200-7201Inferred only
TRHR participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
TRHR participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
TRHR participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
TRHR participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
TRHR participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
TRHR participates in Peptide GPCRsPathwayWikiPathways WP24Inferred only
TRHR participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
TRHR participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
TRHR participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only

Other names

2 names

Resolves to: TRHR

Also called: Thyroliberin receptorTRH-R

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