Proteins/UNIPROT:A6NFA1

TRABD2B

ProteinUNIPROT:A6NFA1

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11..

Function from UniProtKB (A6NFA1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 3 reference databases · Subject: TRABD2B · Sources: gene ontology, Hetionet, UniProt

Order

TRABD2B covaries with CARD19ProteinHetionet hetionet:covaries:388630-84270Inferred only
TRABD2B covaries with HOXB4ProteinHetionet hetionet:covaries:3214-388630Inferred only
TRABD2B covaries with IRX1ProteinHetionet hetionet:covaries:388630-79192Inferred only
TRABD2B covaries with SLC4A3ProteinHetionet hetionet:covaries:388630-6508Inferred only
UBC interacts with TRABD2BProteinHetionet hetionet:interacts:388630-7316Inferred only
TRABD2B regulates negative regulation of Wnt signaling pathwayBiological processgene ontology A6NFA1|GO:0030178Inferred only
TRABD2B regulates positive regulation of protein-containing complex assemblyBiological processgene ontology A6NFA1|GO:0031334Inferred only
TRABD2B requires the cofactor Co(2+)CompoundUniProt A6NFA1Inferred only
TRABD2B requires the cofactor Mn(2+)CompoundUniProt A6NFA1Inferred only

Other names

4 names

Resolves to: TRABD2B

Also called: Heart, kidney and adipose-enriched transmembrane protein homologHKATTIKI2TRAB domain-containing protein 2B

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