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Proteins/UNIPROT:Q86V40
Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation..
Function from UniProtKB (Q86V40), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 statements
5 statements · 3 reference databases · Subject: TRABD2A · Sources: gene ontology, Hetionet, UniProt
3 names
Resolves to: TRABD2A