Proteins/UNIPROT:O15405

TOX3

ProteinUNIPROT:O15405

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region..

Function from UniProtKB (O15405), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 3 reference databases · Subject: TOX3 · Sources: gene ontology, Hetionet, WikiPathways

Order

TOX3 participates in Ectoderm differentiationPathwayWikiPathways WP2858Inferred only
TOX3 participates in Endoderm differentiationPathwayWikiPathways WP2853Inferred only
TOX3 participates in Mesodermal commitment pathwayPathwayWikiPathways WP2857Inferred only
TOX3 regulates negative regulation of neuron apoptotic processBiological processgene ontology O15405|GO:0043524Inferred only
TOX3 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology O15405|GO:0045944Inferred only
TOX3 regulates regulation of apoptotic processBiological processgene ontology O15405|GO:0042981Inferred only
TOX3 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology O15405|GO:0006357Inferred only
TMEM109 increases the expression of TOX3ProteinHetionet hetionet:regulates:79073-27324Inferred only

Other names

4 names

Resolves to: TOX3

Also called: CAG trinucleotide repeat-containing gene F9 proteinCAGF9TNRC9Trinucleotide repeat-containing gene 9 protein

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