Proteins/UNIPROT:Q96B49

TOMM6

ProteinUNIPROT:Q96B49

Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN..

Function from UniProtKB (Q96B49), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

8 statements

8 statements · 2 reference databases · Subject: TOMM6 · Sources: Hetionet, Reactome

Order

TOMM6 covaries with GBX2ProteinHetionet hetionet:covaries:100188893-2637Inferred only
TOMM6 participates in AutophagyPathwayReactome R-HSA-9612973Inferred only
TOMM6 participates in MacroautophagyPathwayReactome R-HSA-1632852Inferred only
TOMM6 participates in Mitochondrial protein importPathwayReactome R-HSA-1268020Inferred only
TOMM6 participates in MitophagyPathwayReactome R-HSA-5205647Inferred only
TOMM6 participates in PINK1-PRKN Mediated MitophagyPathwayReactome R-HSA-5205685Inferred only
TOMM6 participates in Protein localizationPathwayReactome R-HSA-9609507Inferred only
TOMM6 participates in Selective autophagyPathwayReactome R-HSA-9663891Inferred only

Other names

4 names

Resolves to: TOMM6

Also called: OBTPOverexpressed breast tumor proteinTOM6Translocase of outer membrane 6 kDa subunit homolog

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