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© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q13470

TNK1

Protein·UNIPROT:Q13470

Open in the graph

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction..

Function from UniProtKB (Q13470), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

8 statements

8 statements · 2 reference databases · Subject: TNK1 · Sources: Hetionet, WikiPathways

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HSP90AA1 interacts with TNK1ProteinHetionet hetionet:interacts:3320-8711Inferred only
HSP90AB1 interacts with TNK1ProteinHetionet hetionet:interacts:3326-8711Inferred only
PLCG1 interacts with TNK1ProteinHetionet hetionet:interacts:5335-8711Inferred only
UBC interacts with TNK1ProteinHetionet hetionet:interacts:7316-8711Inferred only
TNK1 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
TNK1 participates in Wnt Beta catenin signaling and ARTD family membersPathwayWikiPathways WP5529Inferred only
TNK1 increases the expression of CARMIL1ProteinHetionet hetionet:regulates:8711-55604Inferred only
TNK1 decreases the expression of CCNB1ProteinHetionet hetionet:regulates:8711-891Inferred only

Reactions

1 reaction

L-tyrosyl-[protein]+ATP(4-)O-phospho-L-tyrosyl-[protein]+ADP(3-)+hydron
Catalysed by MAP2K7 or MUSK or RIPK2 or DYRK3 or JAK2 or STK16 or ABL1 or EGFR or ERBB2 or NTRK1 or INSR or LCK and 104 more alternatives
Reaction page

Other names

1 name

Resolves to: TNK1

Also called: CD38 negative kinase 1

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Balance undeterminable

Rhea RHEA:10596CC BY 4.0Reference data