Proteins/UNIPROT:O43508

TNFSF12

ProteinUNIPROT:O43508

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion..

Function from UniProtKB (O43508), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

12 statements

12 statements · 4 reference databases · Subject: TNFSF12 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

TNFSF12 interacts with AGGF1ProteinHetionet hetionet:interacts:55109-8742Inferred only
TNFSF12 participates in Catabolism of skeletal muscle in cachexiaPathwayWikiPathways WP5474Inferred only
TNFSF12 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
TNFSF12 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
TNFSF12 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
TNFSF12 participates in TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayPathwayReactome R-HSA-5676594Inferred only
TNFSF12 participates in TNF related weak inducer of apoptosis TWEAK signalingPathwayWikiPathways WP2036Inferred only
TNFSF12 participates in TNFR2 non-canonical NF-kB pathwayPathwayReactome R-HSA-5668541Inferred only
TNFSF12 regulates positive regulation of angiogenesisBiological processgene ontology O43508|GO:0045766Inferred only
TNFSF12 regulates positive regulation of endothelial cell proliferationBiological processgene ontology O43508|GO:0001938Inferred only
TNFSF12 regulates positive regulation of extrinsic apoptotic signaling pathwayBiological processgene ontology O43508|GO:2001238Inferred only
TNFSF12 regulates positive regulation of protein catabolic processBiological processgene ontology O43508|GO:0045732Inferred only

Other names

5 names

Resolves to: TNFSF12

Also called: APO3 ligandAPO3LDR3LGTNF-related weak inducer of apoptosisTWEAK

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