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Proteins/UNIPROT:P43489

TNFRSF4

Protein·UNIPROT:P43489

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Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity..

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(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B..

Function from UniProtKB (P43489), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

combined immunodeficiency due to OX40 deficiency has a germline basis in TNFRSF4DiseaseGenCC HGNC:11918|MONDO:0014268Inferred only

Statements

15 statements

15 statements · 4 reference databases · Subject: TNFRSF4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CELSR1 covaries with TNFRSF4ProteinHetionet hetionet:covaries:7293-9620Inferred only
TNFRSF9 interacts with TNFRSF4ProteinHetionet hetionet:interacts:3604-7293Inferred only
TNFSF4 interacts with TNFRSF4ProteinHetionet hetionet:interacts:7292-7293Inferred only
TRAF2 interacts with TNFRSF4ProteinHetionet hetionet:interacts:7186-7293Inferred only
TRAF5 interacts with TNFRSF4ProteinHetionet hetionet:interacts:7188-7293Inferred only
TNFRSF4 participates in 1p36 copy number variation syndromePathwayWikiPathways WP5345Inferred only
TNFRSF4 participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
TNFRSF4 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
TNFRSF4 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
TNFRSF4 participates in T cell modulation and desmoplasia in pancreatic cancerPathwayWikiPathways WP5078Inferred only
TNFRSF4 participates in TNFR2 non-canonical NF-kB pathwayPathwayReactome R-HSA-5668541Inferred only
TNFRSF4 participates in TNFs bind their physiological receptorsPathwayReactome R-HSA-5669034Inferred only

Show the remaining 3

TNFRSF4 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology P43489|GO:0000122Inferred only
TNFRSF4 regulates positive regulation of B cell proliferationBiological processgene ontology P43489|GO:0030890Inferred only
TNFRSF4 regulates positive regulation of immunoglobulin productionBiological processgene ontology P43489|GO:0002639Inferred only

Other names

5 names

Resolves to: TNFRSF4

Also called: ACT35 antigenCD antigen CD134OX40L receptorTAX transcriptionally-activated glycoprotein 1 receptorTXGP1L

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