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Proteins/UNIPROT:Q8NEW7

TMIE

Protein·UNIPROT:Q8NEW7

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Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. May contribute to the formation of the pore..

Function from UniProtKB (Q8NEW7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

autosomal recessive nonsyndromic hearing loss 6 has a germline basis in TMIEDiseaseGenCC HGNC:30800|MONDO:0010965Inferred only
hearing loss, autosomal recessive has a germline basis in TMIEDiseaseGenCC HGNC:30800|MONDO:0019588Inferred only
nonsyndromic genetic hearing loss has a germline basis in TMIEDiseaseGenCC HGNC:30800|MONDO:0019497Inferred only

Statements

5 statements

5 statements · 2 reference databases · Subject: TMIE · Sources: Hetionet, Reactome

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TMIE covaries with KRTAP5-5ProteinHetionet hetionet:covaries:259236-439915Inferred only
TMIE participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
TMIE participates in Sensory processing of soundPathwayReactome R-HSA-9659379Inferred only
TMIE participates in Sensory processing of sound by inner hair cells of the cochleaPathwayReactome R-HSA-9662360Inferred only
TMIE participates in Sensory processing of sound by outer hair cells of the cochleaPathwayReactome R-HSA-9662361Inferred only

Other names

1 name

Resolves to: TMIE

Also called: Transmembrane inner ear expressed protein

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