Proteins/UNIPROT:Q6UX40

TMEM107

ProteinUNIPROT:Q6UX40

Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins..

Function from UniProtKB (Q6UX40), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

ciliopathy has a germline basis in TMEM107DiseaseGenCC HGNC:28128|MONDO:0005308Inferred only
Meckel syndrome has a germline basis in TMEM107DiseaseGenCC HGNC:28128|MONDO:0018921Inferred only
Meckel syndrome 13 has a germline basis in TMEM107DiseaseGenCC HGNC:28128|MONDO:0033044Inferred only

Statements

11 statements

11 statements · 2 reference databases · Subject: TMEM107 · Sources: Hetionet, WikiPathways

Order

B3GALNT1 covaries with TMEM107ProteinHetionet hetionet:covaries:84314-8706Inferred only
EPM2AIP1 covaries with TMEM107ProteinHetionet hetionet:covaries:84314-9852Inferred only
KANK3 covaries with TMEM107ProteinHetionet hetionet:covaries:256949-84314Inferred only
LRRC14 covaries with TMEM107ProteinHetionet hetionet:covaries:84314-9684Inferred only
MOGS covaries with TMEM107ProteinHetionet hetionet:covaries:7841-84314Inferred only
SPRED3 covaries with TMEM107ProteinHetionet hetionet:covaries:399473-84314Inferred only
ZFP36 covaries with TMEM107ProteinHetionet hetionet:covaries:7538-84314Inferred only
CLN8 interacts with TMEM107ProteinHetionet hetionet:interacts:2055-84314Inferred only
TMEM107 participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
TMEM107 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
TMEM107 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only

Other names

1 name

Resolves to: TMEM107

Also called: Transmembrane protein 107

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