Proteins/UNIPROT:Q96A25

TMEM106A

ProteinUNIPROT:Q96A25

Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration..

Function from UniProtKB (Q96A25), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

5 statements

5 statements · 2 reference databases · Subject: TMEM106A · Sources: Hetionet, WikiPathways

Order

TMEM106A covaries with ADAMTS7ProteinHetionet hetionet:covaries:11173-113277Inferred only
TMEM106A covaries with CLEC12BProteinHetionet hetionet:covaries:113277-387837Inferred only
OR8I2 covaries with TMEM106AProteinHetionet hetionet:covaries:113277-120586Inferred only
ARF1 interacts with TMEM106AProteinHetionet hetionet:interacts:113277-375Inferred only
TMEM106A participates in TYROBP causal network in microgliaPathwayWikiPathways WP3945Inferred only

Other names

1 name

Resolves to: TMEM106A

Also called: Transmembrane protein 106A

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