Proteins/UNIPROT:Q7Z403

TMC6

ProteinUNIPROT:Q7Z403

Acts as a regulatory protein involved in the regulation of numerous cellular processes. Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally. Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER. Down-regulates the activity of transcription factors induced by zinc and cytokines. Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (By similarity)..

Function from UniProtKB (Q7Z403), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

epidermodysplasia verruciformis has a germline basis in TMC6DiseaseGenCC HGNC:18021|MONDO:0009176Inferred only
epidermodysplasia verruciformis, susceptibility to, 1 has a germline basis in TMC6DiseaseGenCC HGNC:18021|MONDO:0100045Inferred only

Statements

5 statements

5 statements · 2 reference databases · Subject: TMC6 · Sources: Hetionet, Reactome

Order

FHIP2B covaries with TMC6ProteinHetionet hetionet:covaries:11322-64760Inferred only
UBC interacts with TMC6ProteinHetionet hetionet:interacts:11322-7316Inferred only
TMC6 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
TMC6 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
TMC6 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only

Other names

5 names

Resolves to: TMC6

Also called: Epidermodysplasia verruciformis protein 1EVER1EVIN1LAK-4Protein LAK-4

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