Proteins/UNIPROT:Q9NS93

TM7SF3

ProteinUNIPROT:Q9NS93

Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells. Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR)..

Function from UniProtKB (Q9NS93), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 2 reference databases · Subject: TM7SF3 · Sources: gene ontology, Hetionet

Order

TM7SF3 covaries with APOBRProteinHetionet hetionet:covaries:51768-55911Inferred only
TM7SF3 covaries with ETFBKMTProteinHetionet hetionet:covaries:254013-51768Inferred only
TM7SF3 covaries with MADCAM1ProteinHetionet hetionet:covaries:51768-8174Inferred only
TM7SF3 covaries with NGRNProteinHetionet hetionet:covaries:51335-51768Inferred only
PKD1L3 covaries with TM7SF3ProteinHetionet hetionet:covaries:342372-51768Inferred only
TMTC1 covaries with TM7SF3ProteinHetionet hetionet:covaries:51768-83857Inferred only
UBC interacts with TM7SF3ProteinHetionet hetionet:interacts:51768-7316Inferred only
TM7SF3 regulates negative regulation of programmed cell deathBiological processgene ontology Q9NS93|GO:0043069Inferred only
TM7SF3 regulates positive regulation of insulin secretionBiological processgene ontology Q9NS93|GO:0032024Inferred only
ANXA5 increases the expression of TM7SF3ProteinHetionet hetionet:regulates:308-51768Inferred only
ERBB2 decreases the expression of TM7SF3ProteinHetionet hetionet:regulates:2064-51768Inferred only

Other names

2 names

Resolves to: TM7SF3

Also called: Seven span transmembrane proteinTransmembrane 7 superfamily member 3

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