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Proteins/UNIPROT:Q6ZMP0

THSD4

Protein·UNIPROT:Q6ZMP0

Open in the graph

Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN..

Function from UniProtKB (Q6ZMP0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

aortic aneurysm, familial thoracic 12 has a germline basis in THSD4DiseaseGenCC HGNC:25835|MONDO:0030731Inferred only
familial thoracic aortic aneurysm and aortic dissection has a germline basis in THSD4DiseaseGenCC HGNC:25835|MONDO:0019625Inferred only

Statements

13 statements

13 statements · 2 reference databases · Subject: THSD4 · Sources: Hetionet, Reactome

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CIMAP1C covaries with THSD4ProteinHetionet hetionet:covaries:161753-79875Inferred only
LRRC70 covaries with THSD4ProteinHetionet hetionet:covaries:100130733-79875Inferred only
TOPAZ1 covaries with THSD4ProteinHetionet hetionet:covaries:375337-79875Inferred only
ZNF474 covaries with THSD4ProteinHetionet hetionet:covaries:133923-79875Inferred only
THSD4 participates in Defective B3GALTL causes PpSPathwayReactome R-HSA-5083635Inferred only
THSD4 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
THSD4 participates in Diseases associated with O-glycosylation of proteinsPathwayReactome R-HSA-3906995Inferred only
THSD4 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
THSD4 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
THSD4 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
THSD4 participates in O-glycosylation of TSR domain-containing proteinsPathwayReactome R-HSA-5173214Inferred only
THSD4 participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only

Show the remaining 1

THSD4 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only

Other names

3 names

Resolves to: THSD4

Also called: A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6ADAMTS-like protein 6ADAMTSL-6

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