Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P35442

THBS2

Protein·UNIPROT:P35442

Open in the graph

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties..

Function from UniProtKB (P35442), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

Ehlers-Danlos syndrome, classic-like, 3 has a germline basis in THBS2DiseaseGenCC HGNC:11786|MONDO:0971044Inferred only

Statements

23 statements

23 statements · 4 reference databases · Subject: THBS2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

FZR1 covaries with THBS2ProteinHetionet hetionet:covaries:51343-7058Inferred only
MMP2 interacts with THBS2ProteinHetionet hetionet:interacts:4313-7058Inferred only
MMP9 interacts with THBS2ProteinHetionet hetionet:interacts:4318-7058Inferred only
THBS2 interacts with THBS3ProteinHetionet hetionet:interacts:7058-7059Inferred only
THBS2 participates in Defective B3GALTL causes PpSPathwayReactome R-HSA-5083635Inferred only
THBS2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
THBS2 participates in Diseases associated with O-glycosylation of proteinsPathwayReactome R-HSA-3906995Inferred only
THBS2 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
THBS2 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
THBS2 participates in Focal adhesionPathwayWikiPathways WP306Inferred only
THBS2 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
THBS2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only

Show the remaining 11

THBS2 participates in miR 509 3p alteration of YAP1 ECM axisPathwayWikiPathways WP3967Inferred only
THBS2 participates in miRNA targets in ECM and membrane receptorsPathwayWikiPathways WP2911Inferred only
THBS2 participates in O-glycosylation of TSR domain-containing proteinsPathwayReactome R-HSA-5173214Inferred only
THBS2 participates in O-linked glycosylationPathwayReactome R-HSA-5173105Inferred only
THBS2 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
THBS2 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
THBS2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
THBS2 participates in Signaling by PDGFPathwayReactome R-HSA-186797Inferred only
THBS2 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
THBS2 regulates negative regulation of angiogenesisBiological processgene ontology P35442|GO:0016525Inferred only
THBS2 regulates positive regulation of synapse assemblyBiological processgene ontology P35442|GO:0051965Inferred only

Other names

2 names

Resolves to: THBS2

Also called: Thrombospondin-2TSP2

← Every protein Find it in the graph →