Proteins/UNIPROT:Q9NT68

TENM2

ProteinUNIPROT:Q9NT68

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 and ADGRL3 receptors that are expressed at the surface of adjacent cells. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer..

[Isoform 2]: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion..

[Ten-2 intracellular domain]: Induces gene transcription inhibition..

Function from UniProtKB (Q9NT68), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 2 reference databases · Subject: TENM2 · Sources: gene ontology, Hetionet

Order

TENM2 covaries with GJA8ProteinHetionet hetionet:covaries:2703-57451Inferred only
TENM2 covaries with RPL35AProteinHetionet hetionet:covaries:57451-6165Inferred only
TENM2 covaries with SCRT2ProteinHetionet hetionet:covaries:57451-85508Inferred only
TENM2 covaries with SGK3ProteinHetionet hetionet:covaries:23678-57451Inferred only
UBC interacts with TENM2ProteinHetionet hetionet:interacts:57451-7316Inferred only
TENM2 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9NT68|GO:0000122Inferred only
TENM2 regulates positive regulation of filopodium assemblyBiological processgene ontology Q9NT68|GO:0051491Inferred only

Other names

11 names

Resolves to: TENM2

Also called: [Cleaved into: Ten-2, soluble form; Ten-2 intracellular domainKIAA1127Odd Oz/ten-m homolog 2ODZ2Protein Odd Oz/ten-m homolog 2Ten-2Ten-2 ICDTen-m2Tenascin-M2Teneurin transmembrane protein 2TNM2

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