Proteins/UNIPROT:Q9UGU0

TCF20

ProteinUNIPROT:Q9UGU0

Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator..

Function from UniProtKB (Q9UGU0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

developmental delay with variable intellectual impairment and behavioral abnormalities has a germline basis in TCF20DiseaseGenCC HGNC:11631|MONDO:0032745Inferred only
syndromic intellectual disability has a germline basis in TCF20DiseaseGenCC HGNC:11631|MONDO:0000508Inferred only

Statements

18 statements

18 statements · 3 reference databases · Subject: TCF20 · Sources: gene ontology, Hetionet, WikiPathways

Order

ERAP2 covaries with TCF20ProteinHetionet hetionet:covaries:64167-6942Inferred only
TCF20 covaries with RTN4RProteinHetionet hetionet:covaries:65078-6942Inferred only
AR interacts with TCF20ProteinHetionet hetionet:interacts:367-6942Inferred only
ESR1 interacts with TCF20ProteinHetionet hetionet:interacts:2099-6942Inferred only
TCF20 interacts with H2AC20ProteinHetionet hetionet:interacts:6942-8338Inferred only
TCF20 interacts with H2BC21ProteinHetionet hetionet:interacts:6942-8349Inferred only
JUN interacts with TCF20ProteinHetionet hetionet:interacts:3725-6942Inferred only
MAPK14 interacts with TCF20ProteinHetionet hetionet:interacts:1432-6942Inferred only
RNF4 interacts with TCF20ProteinHetionet hetionet:interacts:6047-6942Inferred only
TCF20 interacts with SIRT7ProteinHetionet hetionet:interacts:51547-6942Inferred only
SMAD1 interacts with TCF20ProteinHetionet hetionet:interacts:4086-6942Inferred only
SUMO2 interacts with TCF20ProteinHetionet hetionet:interacts:6613-6942Inferred only

Show the remaining 6

TCF20 interacts with UBCProteinHetionet hetionet:interacts:6942-7316Inferred only
TCF20 participates in Matrix metalloproteinasesPathwayWikiPathways WP129Inferred only
TCF20 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9UGU0|GO:0045944Inferred only
ERBB3 increases the expression of TCF20ProteinHetionet hetionet:regulates:2065-6942Inferred only
MSH6 increases the expression of TCF20ProteinHetionet hetionet:regulates:2956-6942Inferred only
PSMD4 decreases the expression of TCF20ProteinHetionet hetionet:regulates:5710-6942Inferred only

Other names

8 names

Resolves to: TCF20

Also called: AR1KIAA0292Nuclear factor SPBPProtein AR1SPBPSPRE-binding proteinStromelysin-1 PDGF-responsive element-binding proteinTCF-20

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