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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q7L1I2

SV2B

Protein·UNIPROT:Q7L1I2

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Probably plays a role in the control of regulated secretion in neural and endocrine cells..

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(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction. Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1..

Function from UniProtKB (Q7L1I2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

15 statements

15 statements · 3 reference databases · Subject: SV2B · Sources: gene ontology, Hetionet, Reactome

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CHD2 covaries with SV2BProteinHetionet hetionet:covaries:1106-9899Inferred only
PRRT1 covaries with SV2BProteinHetionet hetionet:covaries:80863-9899Inferred only
SV2B interacts with C6orf15ProteinHetionet hetionet:interacts:29113-9899Inferred only
SYT1 interacts with SV2BProteinHetionet hetionet:interacts:6857-9899Inferred only
SV2B participates in Bacterial Infection PathwaysPathwayReactome R-HSA-9824439Inferred only
SV2B participates in DiseasePathwayReactome R-HSA-1643685Inferred only
SV2B participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
SV2B participates in Neurotoxicity of clostridium toxinsPathwayReactome R-HSA-168799Inferred only
SV2B participates in Toxicity of botulinum toxin type A (botA)PathwayReactome R-HSA-5250968Inferred only
SV2B participates in Toxicity of botulinum toxin type D (botD)PathwayReactome R-HSA-5250955Inferred only
SV2B participates in Toxicity of botulinum toxin type E (botE)PathwayReactome R-HSA-5250992Inferred only
SV2B participates in Toxicity of botulinum toxin type F (botF)PathwayReactome R-HSA-5250981Inferred only

Show the remaining 3

SV2B participates in Uptake and actions of bacterial toxinsPathwayReactome R-HSA-5339562Inferred only
SV2B regulates regulation of presynaptic cytosolic calcium ion concentrationBiological processgene ontology Q7L1I2|GO:0099509Inferred only
SV2B regulates regulation of synaptic vesicle exocytosisBiological processgene ontology Q7L1I2|GO:2000300Inferred only

Other names

2 names

Resolves to: SV2B

Also called: KIAA0735Synaptic vesicle glycoprotein 2B

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