Proteins/UNIPROT:P08240

SRPRA

ProteinUNIPROT:P08240

Component of the signal recognition particle (SRP) complex receptor (SR). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54. SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER..

Function from UniProtKB (P08240), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Shwachman-Diamond syndrome has a germline basis in SRPRADiseaseGenCC HGNC:11307|MONDO:0009833Inferred only

Statements

19 statements

19 statements · 2 reference databases · Subject: SRPRA · Sources: Hetionet, Reactome

Order

RPL10A interacts with SRPRAProteinHetionet hetionet:interacts:4736-6734Inferred only
SRPRA interacts with RUSC2ProteinHetionet hetionet:interacts:6734-9853Inferred only
SRPRA interacts with SSR2ProteinHetionet hetionet:interacts:6734-6746Inferred only
SRPRA interacts with UBCProteinHetionet hetionet:interacts:6734-7316Inferred only
SRPRA interacts with UBDProteinHetionet hetionet:interacts:10537-6734Inferred only
SRPRA interacts with UBL4AProteinHetionet hetionet:interacts:6734-8266Inferred only
SRPRA participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
SRPRA participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
SRPRA participates in IRE1alpha activates chaperonesPathwayReactome R-HSA-381070Inferred only
SRPRA participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SRPRA participates in SRP-dependent cotranslational protein targeting to membranePathwayReactome R-HSA-1799339Inferred only
SRPRA participates in TranslationPathwayReactome R-HSA-72766Inferred only

Show the remaining 7

SRPRA participates in Unfolded Protein Response (UPR)PathwayReactome R-HSA-381119Inferred only
SRPRA participates in XBP1(S) activates chaperone genesPathwayReactome R-HSA-381038Inferred only
COG4 increases the expression of SRPRAProteinHetionet hetionet:regulates:25839-6734Inferred only
HSPA5 increases the expression of SRPRAProteinHetionet hetionet:regulates:3309-6734Inferred only
STAT6 increases the expression of SRPRAProteinHetionet hetionet:regulates:6778-6734Inferred only
TM9SF3 increases the expression of SRPRAProteinHetionet hetionet:regulates:56889-6734Inferred only
TPD52L2 increases the expression of SRPRAProteinHetionet hetionet:regulates:7165-6734Inferred only

Other names

4 names

Resolves to: SRPRA

Also called: Docking protein alphaDP-alphaSR-alphaSRPR

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