Proteins/UNIPROT:Q8NFR3

SPTSSB

ProteinUNIPROT:Q8NFR3

Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference..

Function from UniProtKB (Q8NFR3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

5 statements

5 statements · 2 reference databases · Subject: SPTSSB · Sources: Hetionet, Reactome

Order

SPTSSB covaries with ZNF662ProteinHetionet hetionet:covaries:165679-389114Inferred only
SPTSSB participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
SPTSSB participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
SPTSSB participates in Sphingolipid de novo biosynthesisPathwayReactome R-HSA-1660661Inferred only
SPTSSB participates in Sphingolipid metabolismPathwayReactome R-HSA-428157Inferred only

Other names

5 names

Resolves to: SPTSSB

Also called: ADMPC3orf57Protein ADMPSmall subunit of serine palmitoyltransferase BSSSPTB

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