Proteins/UNIPROT:Q8IUH8

SPPL2C

ProteinUNIPROT:Q8IUH8

Sperm-specific intramembrane-cleaving aspartic protease (I-CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins. In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (By similarity). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome..

In round spermatids, acts as a scaffold protein supporting FREY1 in IZUMO1 recruitment at the endoplasmic reticulum membrane and coordination of IZUMO1 complex assembly. Stabilizes FREY1 at the endoplasmic reticulum membrane through interaction. May recruit IZUMO1 interaction partners..

Function from UniProtKB (Q8IUH8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

3 statements

3 statements · 2 reference databases · Subject: SPPL2C · Sources: Hetionet, WikiPathways

Order

SPPL2C covaries with COG8ProteinHetionet hetionet:covaries:162540-84342Inferred only
SPPL2C covaries with MMP25ProteinHetionet hetionet:covaries:162540-64386Inferred only
SPPL2C participates in 11p11 2 copy number variation syndrome PathwayWikiPathways WP5348Inferred only

Other names

4 names

Resolves to: SPPL2C

Also called: IMP-5IMP5Intramembrane protease 5SPP-like 2C

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