Proteins/UNIPROT:O43291

SPINT2

ProteinUNIPROT:O43291

Inhibitor of HGFAC. Also inhibits plasmin, and plasma and tissue kallikrein. Inhibits serine protease activity of TMPRSS13. Inhibits serine protease activity of ST14/matriptase and PRSS8/prostasin in vitro..

Function from UniProtKB (O43291), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

congenital secretory sodium diarrhea 3 has a germline basis in SPINT2DiseaseGenCC HGNC:11247|MONDO:0010036Inferred only
syndromic congenital sodium diarrhea has a germline basis in SPINT2DiseaseGenCC HGNC:11247|MONDO:0034204Inferred only

Statements

21 statements

21 statements · 3 reference databases · Subject: SPINT2 · Sources: gene ontology, Hetionet, Reactome

Order

APP interacts with SPINT2ProteinHetionet hetionet:interacts:10653-351Inferred only
CTSB interacts with SPINT2ProteinHetionet hetionet:interacts:10653-1508Inferred only
HGFAC interacts with SPINT2ProteinHetionet hetionet:interacts:10653-3083Inferred only
ITIH2 interacts with SPINT2ProteinHetionet hetionet:interacts:10653-3698Inferred only
ITIH3 interacts with SPINT2ProteinHetionet hetionet:interacts:10653-3699Inferred only
SPINT2 interacts with SUMO4ProteinHetionet hetionet:interacts:10653-387082Inferred only
UBC interacts with SPINT2ProteinHetionet hetionet:interacts:10653-7316Inferred only
SPINT2 participates in MET Receptor ActivationPathwayReactome R-HSA-6806942Inferred only
SPINT2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SPINT2 participates in Signaling by METPathwayReactome R-HSA-6806834Inferred only
SPINT2 participates in Signaling by MST1PathwayReactome R-HSA-8852405Inferred only
SPINT2 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only

Show the remaining 9

SPINT2 regulates negative regulation of cell motilityBiological processgene ontology O43291|GO:2000146Inferred only
SPINT2 regulates negative regulation of cell-cell adhesionBiological processgene ontology O43291|GO:0022408Inferred only
GTF2E2 increases the expression of SPINT2ProteinHetionet hetionet:regulates:2961-10653Inferred only
LASP1 increases the expression of SPINT2ProteinHetionet hetionet:regulates:3927-10653Inferred only
PPP4R1 increases the expression of SPINT2ProteinHetionet hetionet:regulates:9989-10653Inferred only
RAB4A increases the expression of SPINT2ProteinHetionet hetionet:regulates:5867-10653Inferred only
RIOK2 increases the expression of SPINT2ProteinHetionet hetionet:regulates:55781-10653Inferred only
RRP12 increases the expression of SPINT2ProteinHetionet hetionet:regulates:23223-10653Inferred only
TSHZ3 decreases the expression of SPINT2ProteinHetionet hetionet:regulates:57616-10653Inferred only

Other names

5 names

Resolves to: SPINT2

Also called: HAI-2HAI2Hepatocyte growth factor activator inhibitor type 2KOPPlacental bikunin

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