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Proteins/UNIPROT:Q96N96
Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression..
Function from UniProtKB (Q96N96), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
12 statements
12 statements · 4 reference databases · Subject: SPATA13 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 names
Resolves to: SPATA13