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Proteins/UNIPROT:Q92485
Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity)..
Function from UniProtKB (Q92485), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 statements
5 statements · 3 reference databases · Subject: SMPDL3B · Sources: gene ontology, Hetionet, UniProt
3 names
Resolves to: SMPDL3B