Proteins/UNIPROT:Q9H4I9

SMDT1

ProteinUNIPROT:Q9H4I9

Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 with the calcium-conducting subunit MCU. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling..

Function from UniProtKB (Q9H4I9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 2 reference databases · Subject: SMDT1 · Sources: Hetionet, Reactome

Order

FAM162B covaries with SMDT1ProteinHetionet hetionet:covaries:221303-91689Inferred only
SMDT1 covaries with TMEM238ProteinHetionet hetionet:covaries:388564-91689Inferred only
SMDT1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SMDT1 participates in Mitochondrial calcium ion transportPathwayReactome R-HSA-8949215Inferred only
SMDT1 participates in Mitochondrial protein degradationPathwayReactome R-HSA-9837999Inferred only
SMDT1 participates in Processing of SMDT1PathwayReactome R-HSA-8949664Inferred only
SMDT1 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only

Other names

4 names

Resolves to: SMDT1

Also called: C22orf32EMREEssential MCU regulator, mitochondrialSingle-pass membrane protein with aspartate-rich tail 1, mitochondrial

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