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A reference for what the literature reports. Not medical advice.

Proteins/UNIPROT:Q8IYM2

SLFN12

Protein·UNIPROT:Q8IYM2

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Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. May play a role in cell differentiation..

Function from UniProtKB (Q8IYM2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

2 statements

2 statements · 2 reference databases · Subject: SLFN12 · Sources: Hetionet, WikiPathways

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UBC interacts with SLFN12ProteinHetionet hetionet:interacts:55106-7316Inferred only
SLFN12 participates in 17q12 copy number variation syndromePathwayWikiPathways WP5287Inferred only

Other names

1 name

Resolves to: SLFN12

Also called: Schlafen family member 12

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