Proteins/UNIPROT:O00241

SIRPB1

ProteinUNIPROT:O00241

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP..

Function from UniProtKB (O00241), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 3 reference databases · Subject: SIRPB1 · Sources: gene ontology, Hetionet, Reactome

Order

TYROBP interacts with SIRPB1ProteinHetionet hetionet:interacts:10326-7305Inferred only
UBC interacts with SIRPB1ProteinHetionet hetionet:interacts:10326-7316Inferred only
SIRPB1 participates in Cell-Cell communicationPathwayReactome R-HSA-1500931Inferred only
SIRPB1 participates in DAP12 interactionsPathwayReactome R-HSA-2172127Inferred only
SIRPB1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
SIRPB1 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
SIRPB1 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
SIRPB1 participates in Signal regulatory protein family interactionsPathwayReactome R-HSA-391160Inferred only
SIRPB1 regulates positive regulation of phagocytosisBiological processgene ontology O00241|GO:0050766Inferred only
SIRPB1 regulates positive regulation of T cell activationBiological processgene ontology O00241|GO:0050870Inferred only

Other names

3 names

Resolves to: SIRPB1

Also called: CD antigen CD172bCD172 antigen-like family member BSIRP-beta-1

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