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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9NYZ4

SIGLEC8

Protein·UNIPROT:Q9NYZ4

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Putative adhesion molecule that mediates sialic-acid dependent binding to blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes..

Function from UniProtKB (Q9NYZ4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

4 statements

4 statements · 2 reference databases · Subject: SIGLEC8 · Sources: Hetionet, Reactome

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TFF1 interacts with SIGLEC8ProteinHetionet hetionet:interacts:27181-7031Inferred only
SIGLEC8 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
SIGLEC8 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
SIGLEC8 participates in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellPathwayReactome R-HSA-198933Inferred only

Other names

4 names

Resolves to: SIGLEC8

Also called: SAF-2SAF2Sialoadhesin family member 2Siglec-8

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