Proteins/UNIPROT:Q8TBC3

SHKBP1

ProteinUNIPROT:Q8TBC3

Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation..

Function from UniProtKB (Q8TBC3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

22 statements

22 statements · 3 reference databases · Subject: SHKBP1 · Sources: gene ontology, Hetionet, Reactome

Order

BAALC covaries with SHKBP1ProteinHetionet hetionet:covaries:79870-92799Inferred only
SHKBP1 covaries with CCR10ProteinHetionet hetionet:covaries:2826-92799Inferred only
MAPK1 covaries with SHKBP1ProteinHetionet hetionet:covaries:5594-92799Inferred only
SHKBP1 covaries with SOSTProteinHetionet hetionet:covaries:50964-92799Inferred only
SHKBP1 covaries with ZNF383ProteinHetionet hetionet:covaries:163087-92799Inferred only
CCNG1 interacts with SHKBP1ProteinHetionet hetionet:interacts:900-92799Inferred only
COL7A1 interacts with SHKBP1ProteinHetionet hetionet:interacts:1294-92799Inferred only
COPS5 interacts with SHKBP1ProteinHetionet hetionet:interacts:10987-92799Inferred only
CUL3 interacts with SHKBP1ProteinHetionet hetionet:interacts:8452-92799Inferred only
DCUN1D1 interacts with SHKBP1ProteinHetionet hetionet:interacts:54165-92799Inferred only
GRB2 interacts with SHKBP1ProteinHetionet hetionet:interacts:2885-92799Inferred only
MMS19 interacts with SHKBP1ProteinHetionet hetionet:interacts:64210-92799Inferred only

Show the remaining 10

NEDD8 interacts with SHKBP1ProteinHetionet hetionet:interacts:4738-92799Inferred only
PIN1 interacts with SHKBP1ProteinHetionet hetionet:interacts:5300-92799Inferred only
SH3KBP1 interacts with SHKBP1ProteinHetionet hetionet:interacts:30011-92799Inferred only
UBC interacts with SHKBP1ProteinHetionet hetionet:interacts:7316-92799Inferred only
SHKBP1 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
SHKBP1 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
SHKBP1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
SHKBP1 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
SHKBP1 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
SHKBP1 regulates positive regulation of epidermal growth factor receptor signaling pathwayBiological processgene ontology Q8TBC3|GO:0045742Inferred only

Other names

3 names

Resolves to: SHKBP1

Also called: SB1SETA-binding protein 1SH3KBP1-binding protein 1

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