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Proteins/UNIPROT:Q96ES7
Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me. Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival. Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-506' (By similarity)..
Function from UniProtKB (Q96ES7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
31 statements
31 statements · 3 reference databases · Subject: SGF29 · Sources: gene ontology, Hetionet, Reactome
3 names
Resolves to: SGF29