Proteins/UNIPROT:P04279

SEMG1

ProteinUNIPROT:P04279

Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA..

Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone..

Function from UniProtKB (P04279), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 4 reference databases · Subject: SEMG1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

CDK2 interacts with SEMG1ProteinHetionet hetionet:interacts:1017-6406Inferred only
SEMG1 interacts with SEMG2ProteinHetionet hetionet:interacts:6406-6407Inferred only
SEMG1 interacts with UBCProteinHetionet hetionet:interacts:6406-7316Inferred only
SEMG1 interacts with UBQLN4ProteinHetionet hetionet:interacts:56893-6406Inferred only
SEMG1 participates in Amyloid fiber formationPathwayReactome R-HSA-977225Inferred only
SEMG1 participates in Antimicrobial peptidesPathwayReactome R-HSA-6803157Inferred only
SEMG1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
SEMG1 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
SEMG1 participates in Male infertilityPathwayWikiPathways WP4673Inferred only
SEMG1 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SEMG1 regulates negative regulation of calcium ion importBiological processgene ontology P04279|GO:0090281Inferred only
SEMG1 regulates negative regulation of flagellated sperm motilityBiological processgene ontology P04279|GO:1901318Inferred only

Show the remaining 1

SEMG1 regulates positive regulation of serine-type endopeptidase activityBiological processgene ontology P04279|GO:1900005Inferred only

Other names

5 names

Resolves to: SEMG1

Also called: [Cleaved into: Alpha-inhibin-92; Alpha-inhibin-31; Seminal basic protein]Cancer/testis antigen 103Semenogelin ISEMGSGI

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