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Proteins/UNIPROT:O94979

SEC31A

Protein·UNIPROT:O94979

Open in the graph

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity)..

Function from UniProtKB (O94979), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

neurodevelopmental disorder with spastic quadriplegia, optic atrophy, seizures, and structural brain anomalies has a germline basis in SEC31ADiseaseGenCC HGNC:17052|MONDO:0032849Inferred only

Statements

37 statements

37 statements · 4 reference databases · Subject: SEC31A · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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SEC31A covaries with OXER1ProteinHetionet hetionet:covaries:165140-22872Inferred only
APC interacts with SEC31AProteinHetionet hetionet:interacts:22872-324Inferred only
MYOM2 interacts with SEC31AProteinHetionet hetionet:interacts:22872-9172Inferred only
PDCD6 interacts with SEC31AProteinHetionet hetionet:interacts:10016-22872Inferred only
PFDN1 interacts with SEC31AProteinHetionet hetionet:interacts:22872-5201Inferred only
SEC13 interacts with SEC31AProteinHetionet hetionet:interacts:22872-6396Inferred only
TNNT1 interacts with SEC31AProteinHetionet hetionet:interacts:22872-7138Inferred only
SEC31A participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
SEC31A participates in Antigen Presentation: Folding, assembly and peptide loading of class I MHCPathwayReactome R-HSA-983170Inferred only
SEC31A participates in Asparagine N-linked glycosylationPathwayReactome R-HSA-446203Inferred only
SEC31A participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
SEC31A participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only

Show the remaining 25

SEC31A participates in Class I MHC mediated antigen processing & presentationPathwayReactome R-HSA-983169Inferred only
SEC31A participates in COPII-mediated vesicle transportPathwayReactome R-HSA-204005Inferred only
SEC31A participates in DiseasePathwayReactome R-HSA-1643685Inferred only
SEC31A participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
SEC31A participates in ER to Golgi Anterograde TransportPathwayReactome R-HSA-199977Inferred only
SEC31A participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
SEC31A participates in IRE1alpha activates chaperonesPathwayReactome R-HSA-381070Inferred only
SEC31A participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
SEC31A participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
SEC31A participates in MHC class II antigen presentationPathwayReactome R-HSA-2132295Inferred only
SEC31A participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
SEC31A participates in Signaling by ALK fusions and activated point mutantsPathwayReactome R-HSA-9725370Inferred only
SEC31A participates in Signaling by ALK in cancerPathwayReactome R-HSA-9700206Inferred only
SEC31A participates in Sterol regulatory element binding proteins SREBP signalingPathwayWikiPathways WP1982Inferred only
SEC31A participates in Transport to the Golgi and subsequent modificationPathwayReactome R-HSA-948021Inferred only
SEC31A participates in Unfolded Protein Response (UPR)PathwayReactome R-HSA-381119Inferred only
SEC31A participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
SEC31A participates in XBP1(S) activates chaperone genesPathwayReactome R-HSA-381038Inferred only
SEC31A regulates positive regulation of ER to Golgi vesicle-mediated transportBiological processgene ontology O94979|GO:1902953Inferred only
SEC31A regulates positive regulation of protein exit from endoplasmic reticulumBiological processgene ontology O94979|GO:0070863Inferred only
CAPNS2 increases the expression of SEC31AProteinHetionet hetionet:regulates:84290-22872Inferred only
CDK4 increases the expression of SEC31AProteinHetionet hetionet:regulates:1019-22872Inferred only
COPA increases the expression of SEC31AProteinHetionet hetionet:regulates:1314-22872Inferred only
TM9SF3 increases the expression of SEC31AProteinHetionet hetionet:regulates:56889-22872Inferred only
TRAPPC3 increases the expression of SEC31AProteinHetionet hetionet:regulates:27095-22872Inferred only

Other names

7 names

Resolves to: SEC31A

Also called: ABP125ABP130KIAA0905SEC31-like protein 1SEC31-related protein ASEC31L1Web1-like protein

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