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Proteins/UNIPROT:Q6IQ49
Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress. SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage..
Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content. May recruit CACTIN to the spliceosome (By similarity)..
Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor. Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118..
Function from UniProtKB (Q6IQ49), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
7 statements
7 statements · 2 reference databases · Subject: SDE2 · Sources: Hetionet, Reactome
3 names
Resolves to: SDE2