Proteins/UNIPROT:Q86SQ7

SDCCAG8

ProteinUNIPROT:Q86SQ7

Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis..

Function from UniProtKB (Q86SQ7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

5 rows

Bardet-Biedl syndrome has a germline basis in SDCCAG8DiseaseGenCC HGNC:10671|MONDO:0015229Inferred only
Bardet-Biedl syndrome 16 has a germline basis in SDCCAG8DiseaseGenCC HGNC:10671|MONDO:0014444Inferred only
ciliopathy has a germline basis in SDCCAG8DiseaseGenCC HGNC:10671|MONDO:0005308Inferred only
Senior-Loken syndrome has a germline basis in SDCCAG8DiseaseGenCC HGNC:10671|MONDO:0017842Inferred only
Senior-Loken syndrome 7 has a germline basis in SDCCAG8DiseaseGenCC HGNC:10671|MONDO:0013326Inferred only

Statements

24 statements

24 statements · 4 reference databases · Subject: SDCCAG8 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

SAXO2 covaries with SDCCAG8ProteinHetionet hetionet:covaries:10806-283726Inferred only
TRAF6 interacts with SDCCAG8ProteinHetionet hetionet:interacts:10806-7189Inferred only
TSC1 interacts with SDCCAG8ProteinHetionet hetionet:interacts:10806-7248Inferred only
SDCCAG8 participates in 16p11 2 distal deletion syndromePathwayWikiPathways WP4950Inferred only
SDCCAG8 participates in Anchoring of the basal body to the plasma membranePathwayReactome R-HSA-5620912Inferred only
SDCCAG8 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
SDCCAG8 participates in AURKA Activation by TPX2PathwayReactome R-HSA-8854518Inferred only
SDCCAG8 participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
SDCCAG8 participates in Cell CyclePathwayReactome R-HSA-1640170Inferred only
SDCCAG8 participates in Cell Cycle, MitoticPathwayReactome R-HSA-69278Inferred only
SDCCAG8 participates in Centrosome maturationPathwayReactome R-HSA-380287Inferred only
SDCCAG8 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only

Show the remaining 12

SDCCAG8 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
SDCCAG8 participates in G2/M TransitionPathwayReactome R-HSA-69275Inferred only
SDCCAG8 participates in Loss of Nlp from mitotic centrosomesPathwayReactome R-HSA-380259Inferred only
SDCCAG8 participates in Loss of proteins required for interphase microtubule organization from the centrosomePathwayReactome R-HSA-380284Inferred only
SDCCAG8 participates in M PhasePathwayReactome R-HSA-68886Inferred only
SDCCAG8 participates in Mitotic G2-G2/M phasesPathwayReactome R-HSA-453274Inferred only
SDCCAG8 participates in Mitotic PrometaphasePathwayReactome R-HSA-68877Inferred only
SDCCAG8 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
SDCCAG8 participates in Recruitment of mitotic centrosome proteins and complexesPathwayReactome R-HSA-380270Inferred only
SDCCAG8 participates in Recruitment of NuMA to mitotic centrosomesPathwayReactome R-HSA-380320Inferred only
SDCCAG8 participates in Regulation of PLK1 Activity at G2/M TransitionPathwayReactome R-HSA-2565942Inferred only
SDCCAG8 regulates regulation of cilium assemblyBiological processgene ontology Q86SQ7|GO:1902017Inferred only

Other names

5 names

Resolves to: SDCCAG8

Also called: Antigen NY-CO-8CCCAPCentrosomal colon cancer autoantigen proteinhCCCAPNPHP10

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