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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:O75880

SCO1

Protein·UNIPROT:O75880

Open in the graph

Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Together with SCO2, involved in delivering copper to the Cu(A) site on MT-CO2/COX2. Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (By similarity)..

Function from UniProtKB (O75880), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

mitochondrial complex IV deficiency, nuclear type 4 has a germline basis in SCO1DiseaseGenCC HGNC:10603|MONDO:0033636Inferred only
mitochondrial disease has a germline basis in SCO1DiseaseGenCC HGNC:10603|MONDO:0044970Inferred only

Statements

8 statements

8 statements · 3 reference databases · Subject: SCO1 · Sources: Hetionet, Reactome, WikiPathways

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SCO1 interacts with COX17ProteinHetionet hetionet:interacts:10063-6341Inferred only
SCO1 interacts with UBCProteinHetionet hetionet:interacts:6341-7316Inferred only
SCO1 participates in Aerobic respiration and respiratory electron transportPathwayReactome R-HSA-1428517Inferred only
SCO1 participates in Complex IV assemblyPathwayReactome R-HSA-9864848Inferred only
SCO1 participates in Copper homeostasisPathwayWikiPathways WP3286Inferred only
SCO1 participates in Electron transport chain OXPHOS system in mitochondriaPathwayWikiPathways WP111Inferred only
SCO1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
SCO1 participates in Respiratory electron transportPathwayReactome R-HSA-611105Inferred only

Other names

2 names

Resolves to: SCO1

Also called: Cytochrome c oxidase assembly factor SCO1SCOD1

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