Proteins/UNIPROT:Q9H228

S1PR5

ProteinUNIPROT:Q9H228

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells..

Function from UniProtKB (Q9H228), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

13 statements

13 statements · 3 reference databases · Subject: S1PR5 · Sources: Hetionet, Reactome, WikiPathways

Order

GNA12 interacts with S1PR5ProteinHetionet hetionet:interacts:2768-53637Inferred only
GNAO1 interacts with S1PR5ProteinHetionet hetionet:interacts:2775-53637Inferred only
S1PR5 interacts with SGPP1ProteinHetionet hetionet:interacts:53637-81537Inferred only
S1PR5 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
S1PR5 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
S1PR5 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
S1PR5 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
S1PR5 participates in Lysosphingolipid and LPA receptorsPathwayReactome R-HSA-419408Inferred only
S1PR5 participates in Multiple sclerosis mechanism and therapiesPathwayWikiPathways WP5540Inferred only
S1PR5 participates in S1P receptor signal transductionPathwayWikiPathways WP26Inferred only
S1PR5 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
S1PR5 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only

Show the remaining 1

S1PR5 participates in Sphingolipid metabolism in senescencePathwayWikiPathways WP5121Inferred only

Other names

6 names

Resolves to: S1PR5

Also called: EDG8Endothelial differentiation G protein-coupled receptor 8S1P receptor 5S1P receptor Edg-8S1P5Sphingosine 1-phosphate receptor Edg-8

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