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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q96K19

RNF170

Protein·UNIPROT:Q96K19

Open in the graph

E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Selectively inhibits the TLR3-triggered innate immune response by promoting the 'Lys-48'-linked polyubiquitination and degradation of TLR3..

Function from UniProtKB (Q96K19), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

autosomal dominant sensory ataxia 1 has a germline basis in RNF170DiseaseGenCC HGNC:25358|MONDO:0012166Inferred only
spastic paraplegia 85, autosomal recessive has a germline basis in RNF170DiseaseGenCC HGNC:25358|MONDO:0030512Inferred only

Statements

3 statements

3 statements · 2 reference databases · Subject: RNF170 · Sources: gene ontology, Hetionet

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UBC interacts with RNF170ProteinHetionet hetionet:interacts:7316-81790Inferred only
RNF170 interacts with UBE2UProteinHetionet hetionet:interacts:148581-81790Inferred only
RNF170 regulates negative regulation of toll-like receptor 3 signaling pathwayBiological processgene ontology Q96K19|GO:0034140Inferred only

Other names

3 names

Resolves to: RNF170

Also called: Putative LAG1-interacting proteinRING finger protein 170RING-type E3 ubiquitin transferase RNF170

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