Proteins/UNIPROT:Q6P5S7

RNASEK

ProteinUNIPROT:Q6P5S7

Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate. Regulates the activity of vacuolar (H+)-ATPase (V-ATPase) which is responsible for acidifying and maintaining the pH of intracellular compartments. Required at an early stage of receptor-mediated endocytosis..

(Microbial infection) Required at an early stage of both clathrin-mediated and clathrin-independent endocytic uptake of a diverse set of viruses, including dengue, West Nile, Sindbis, Rift Valley Fever, influenza, and human rhinoviruses..

Function from UniProtKB (Q6P5S7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 2 reference databases · Subject: RNASEK · Sources: Hetionet, Reactome

Order

ATP6V0C covaries with RNASEKProteinHetionet hetionet:covaries:440400-527Inferred only
ATP6V1E1 covaries with RNASEKProteinHetionet hetionet:covaries:440400-529Inferred only
JOSD2 covaries with RNASEKProteinHetionet hetionet:covaries:126119-440400Inferred only
PPP1R27 covaries with RNASEKProteinHetionet hetionet:covaries:116729-440400Inferred only
UBC interacts with RNASEKProteinHetionet hetionet:interacts:440400-7316Inferred only
RNASEK participates in Dengue Virus Attachment and EntryPathwayReactome R-HSA-9918485Inferred only
RNASEK participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
RNASEK participates in DiseasePathwayReactome R-HSA-1643685Inferred only
RNASEK participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
RNASEK participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only

Other names

4 names

Resolves to: RNASEK

Also called: RNase KRNase kappaV-ATPase subunit fV-type proton ATPase subunit f

← Every protein Find it in the graph →