Proteins/UNIPROT:Q96K30

RITA1

ProteinUNIPROT:Q96K30

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis..

Function from UniProtKB (Q96K30), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 2 reference databases · Subject: RITA1 · Sources: gene ontology, Hetionet

Order

EXOSC6 covaries with RITA1ProteinHetionet hetionet:covaries:118460-84934Inferred only
GAS1 covaries with RITA1ProteinHetionet hetionet:covaries:2619-84934Inferred only
HIRIP3 covaries with RITA1ProteinHetionet hetionet:covaries:8479-84934Inferred only
IFNL1 covaries with RITA1ProteinHetionet hetionet:covaries:282618-84934Inferred only
JSRP1 covaries with RITA1ProteinHetionet hetionet:covaries:126306-84934Inferred only
PCDHB8 covaries with RITA1ProteinHetionet hetionet:covaries:56128-84934Inferred only
PLK4 covaries with RITA1ProteinHetionet hetionet:covaries:10733-84934Inferred only
TAS2R40 covaries with RITA1ProteinHetionet hetionet:covaries:259286-84934Inferred only
TOB2 covaries with RITA1ProteinHetionet hetionet:covaries:10766-84934Inferred only
APP interacts with RITA1ProteinHetionet hetionet:interacts:351-84934Inferred only
RBPJ interacts with RITA1ProteinHetionet hetionet:interacts:3516-84934Inferred only
RITA1 regulates negative regulation of Notch signaling pathwayBiological processgene ontology Q96K30|GO:0045746Inferred only

Show the remaining 3

RITA1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q96K30|GO:0000122Inferred only
KTN1 increases the expression of RITA1ProteinHetionet hetionet:regulates:3895-84934Inferred only
PRKCZ increases the expression of RITA1ProteinHetionet hetionet:regulates:5590-84934Inferred only

Other names

4 names

Resolves to: RITA1

Also called: C12orf52RBPJ-interacting and tubulin-associated proteinRBPJ-interacting and tubulin-associated protein 1RITA

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