Proteins/UNIPROT:Q8WYP3

RIN2

ProteinUNIPROT:Q8WYP3

Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP..

Function from UniProtKB (Q8WYP3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

RIN2 syndrome has a germline basis in RIN2DiseaseGenCC HGNC:18750|MONDO:0013115Inferred only

Statements

17 statements

17 statements · 3 reference databases · Subject: RIN2 · Sources: gene ontology, Hetionet, Reactome

Order

RIN2 covaries with FKBP10ProteinHetionet hetionet:covaries:54453-60681Inferred only
PTPRM covaries with RIN2ProteinHetionet hetionet:covaries:54453-5797Inferred only
BIN1 interacts with RIN2ProteinHetionet hetionet:interacts:274-54453Inferred only
EGFR interacts with RIN2ProteinHetionet hetionet:interacts:1956-54453Inferred only
ERBB2 interacts with RIN2ProteinHetionet hetionet:interacts:2064-54453Inferred only
RAB5A interacts with RIN2ProteinHetionet hetionet:interacts:54453-5868Inferred only
RAB5B interacts with RIN2ProteinHetionet hetionet:interacts:54453-5869Inferred only
RAB5C interacts with RIN2ProteinHetionet hetionet:interacts:54453-5878Inferred only
RIN2 participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
RIN2 participates in RAB GEFs exchange GTP for GDP on RABsPathwayReactome R-HSA-8876198Inferred only
RIN2 participates in Rab regulation of traffickingPathwayReactome R-HSA-9007101Inferred only
RIN2 participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Show the remaining 5

RIN2 regulates positive regulation of endothelial cell migrationBiological processgene ontology Q8WYP3|GO:0010595Inferred only
RIN2 regulates positive regulation of endothelial cell-matrix adhesionBiological processgene ontology Q8WYP3|GO:1904906Inferred only
RIN2 regulates positive regulation of vasculogenesisBiological processgene ontology Q8WYP3|GO:2001214Inferred only
DYRK1A decreases the expression of RIN2ProteinHetionet hetionet:regulates:1859-54453Inferred only
SOX2 decreases the expression of RIN2ProteinHetionet hetionet:regulates:6657-54453Inferred only

Other names

4 names

Resolves to: RIN2

Also called: Ras association domain family 4Ras inhibitor JC265Ras interaction/interference protein 2RASSF4

← Every protein Find it in the graph →