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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:P57771

RGS8

Protein·UNIPROT:P57771

Open in the graph

Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity)..

Function from UniProtKB (P57771), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

7 statements

7 statements · 2 reference databases · Subject: RGS8 · Sources: gene ontology, Reactome

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RGS8 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
RGS8 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
RGS8 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
RGS8 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
RGS8 regulates negative regulation of G protein-coupled receptor signaling pathwayBiological processgene ontology P57771|GO:0045744Inferred only
RGS8 regulates positive regulation of GTPase activityBiological processgene ontology P57771|GO:0043547Inferred only
RGS8 regulates regulation of dopamine receptor signaling pathwayBiological processgene ontology P57771|GO:0060159Inferred only

Other names

1 name

Resolves to: RGS8

Also called: Regulator of G protein signaling 8

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