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Proteins/UNIPROT:P49758

RGS6

Protein·UNIPROT:P49758

Open in the graph

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity..

Function from UniProtKB (P49758), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

16 statements

16 statements · 4 reference databases · Subject: RGS6 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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RGS6 interacts with DMAP1ProteinHetionet hetionet:interacts:55929-9628Inferred only
RGS6 interacts with GNB5ProteinHetionet hetionet:interacts:10681-9628Inferred only
HSP90AB1 interacts with RGS6ProteinHetionet hetionet:interacts:3326-9628Inferred only
RGS6 interacts with STMN2ProteinHetionet hetionet:interacts:11075-9628Inferred only
RGS6 participates in Calcium regulation in cardiac cellsPathwayWikiPathways WP536Inferred only
RGS6 participates in Chaperonin-mediated protein foldingPathwayReactome R-HSA-390466Inferred only
RGS6 participates in Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingPathwayReactome R-HSA-6814122Inferred only
RGS6 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
RGS6 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
RGS6 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
RGS6 participates in Myometrial relaxation and contraction pathwaysPathwayWikiPathways WP289Inferred only
RGS6 participates in Protein foldingPathwayReactome R-HSA-391251Inferred only

Show the remaining 4

RGS6 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
RGS6 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
RGS6 regulates positive regulation of GTPase activityBiological processgene ontology P49758|GO:0043547Inferred only
RGS6 regulates regulation of G protein-coupled receptor signaling pathwayBiological processgene ontology P49758|GO:0008277Inferred only

Other names

1 name

Resolves to: RGS6

Also called: S914

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