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Proteins/UNIPROT:P10082
[Peptide YY]: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Also binds NPY5R (By similarity). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by PYY also leads to an increase of intracellular Ca(2+) levels. This gut peptide inhibits exocrine pancreatic secretion (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity)..
[Peptide YY(3-36)]: Is a NPY2R agonist involved in the down-regulation of appetite and food intake, probably acting on receptors located on proopiomelanocortin(POMC)-releasing and neuropeptide Y(NPY)-releasing neurons in the arcuate nucleus of hypothalamus. In NPY-releasing neurons, NPY2R activation by PYY(3-36) leads to membrane hyperpolarization and reduced release of the orexigenic neuropeptide NPY (By similarity)..
Function from UniProtKB (P10082), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
12 statements
12 statements · 4 reference databases · Subject: PYY · Sources: gene ontology, Hetionet, Reactome, WikiPathways
5 names
Resolves to: PYY