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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q9Y5Y4

PTGDR2

Protein·UNIPROT:Q9Y5Y4

Open in the graph

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses..

Function from UniProtKB (Q9Y5Y4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

11 statements

11 statements · 3 reference databases · Subject: PTGDR2 · Sources: Hetionet, Reactome, WikiPathways

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PTGDR2 interacts with ANKRD13CProteinHetionet hetionet:interacts:11251-81573Inferred only
PTGDR2 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
PTGDR2 participates in Eicosanoid ligand-binding receptorsPathwayReactome R-HSA-391903Inferred only
PTGDR2 participates in Eicosanoid metabolism via cyclooxygenases COX PathwayWikiPathways WP4719Inferred only
PTGDR2 participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
PTGDR2 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
PTGDR2 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
PTGDR2 participates in GPCRs class A rhodopsin likePathwayWikiPathways WP455Inferred only
PTGDR2 participates in Prostanoid ligand receptorsPathwayReactome R-HSA-391908Inferred only
PTGDR2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PTGDR2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only

Other names

6 names

Resolves to: PTGDR2

Also called: CD antigen CD294Chemoattractant receptor-homologous molecule expressed on Th2 cellsCRTH2DL1RG protein-coupled receptor 44GPR44

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