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Proteins/UNIPROT:Q6ISU1

PTCRA

Protein·UNIPROT:Q6ISU1

Open in the graph

Component of the pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) that has a crucial role in early T-cell development, particularly alpha-beta T cell differentiation..

Function from UniProtKB (Q6ISU1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

immunodeficiency 126, susceptibility to has a germline basis in PTCRADiseaseGenCC HGNC:21290|MONDO:0975761Inferred only

Statements

10 statements

10 statements · 4 reference databases · Subject: PTCRA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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NOTCH3 interacts with PTCRAProteinHetionet hetionet:interacts:171558-4854Inferred only
UBC interacts with PTCRAProteinHetionet hetionet:interacts:171558-7316Inferred only
PTCRA participates in Acute viral myocarditisPathwayWikiPathways WP4298Inferred only
PTCRA participates in Extrafollicular and follicular B cell activation by SARS CoV 2PathwayWikiPathways WP5218Inferred only
PTCRA participates in Notch signalingPathwayWikiPathways WP268Inferred only
PTCRA participates in NOTCH3 Intracellular Domain Regulates TranscriptionPathwayReactome R-HSA-9013508Inferred only
PTCRA participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PTCRA participates in Signaling by NOTCHPathwayReactome R-HSA-157118Inferred only
PTCRA participates in Signaling by NOTCH3PathwayReactome R-HSA-9012852Inferred only
PTCRA regulates negative regulation of thymocyte apoptotic processBiological processgene ontology Q6ISU1|GO:0070244Inferred only

Other names

3 names

Resolves to: PTCRA

Also called: pT-alphapT-alpha-TCRpTa

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